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Desmopressin Acetate ( des-moe-PRES-in AS-ih-tate ) (Stimate®, DDAVP® Nocdurna) What is this medication used for?
Desmopressin acetate increases levels of factor VIII and von Willebrand factor in patients with mild hemophilia and Type 1 von Willebrand disease. Desmopressin acetate can also be used to treat diabetes insipidus and works by replacing vasopressin, a hormone that is normally produced in the body to help balance the amount of water and salt.
What does it look like? • Liquid • Tablet How is it given? • In the nose (intranasal)
Special instructions: • The Stimate® and DDAVP® A challenge test may be performed to determine individual patient response before beginning this medication. • If the intranasal form is being used, prime the spray bottle the first time by spraying five times into the air (away from the face) until you see a fine mist. If the medicine isn’t use for more than 7 days, prime it again by spraying once. Throw away the bottle and any unused medication after 50 days. • The amount of fluid taken by mouth may be limited by the healthcare provider. Follow instructions carefully to prevent unwanted side effects. • Notify a healthcare provider if extra fluid is consumed due to hot weather, strenuouse exercise or severe vomiting or diarrhea. • Notify the health care provider of a seizure disorder before beginning this medication • If a dose is missed, take it as soon as possible. If it is almost time for the next dose, take only that dose. Do not take double or extra doses. • Monitoring blood pressure and frequent blood tests may be necessary.
• Into the vein (IV) or venous access device • Under the skin (subcutaneous or subq) • By mouth (oral or PO) What are the common side effects? • Changes in blood pressure • Increased heart rate • Headache • Flushing of face • Nausea • Tiredness • Abdominal cramps • Low sodium levels • Sudden weight gain • Swelling of the legs or ankles What are the less common side effects? • Fluid and electrolyte imbalance • Seizures because of low sodium levels • Blood clots
• Allergic reactions (e.g., itching or hives, swelling in the face or hands, swelling or tingling in the mouth or throat, chest tightness, trouble breathing) • Confusion, weakness, muscle twitching, and weight gain because of fluid or electrolyte imbalances
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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