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Dactinomycin ( dak-ti-noe-MYE-sin ) (Actinomycin D, Cosmegen®) What is this medication used for? Dactinomycin destroys cancer cells by interfering with their growth cycle.
What does it look like? • Liquid How is it given?
What are rare but serious side effects? • Severe allergic reaction (anaphylaxis) • Development of a new cancer or leukemia Special instructions: • Use sunscreen and wear protective clothing when outdoors.
• Into the vein (IV) or venous access device What are the common side effects?
• Nausea or vomiting • Hair loss (alopecia) • Mouth sores • Low blood counts What are the less common side effects? • Inflammation of lips, mouth, throat, esophagus, intestine, or rectum • Skin damage if the medicine leaks out of the vein • Decreased appetite • Redness, burning, or darkening of skin that received radiation therapy • Feeling tired or weak (fatigue, malaise) • Changes to liver function tests
• This medicine can cause irritation if it leaks out of the vein. Tell the person giving the medicine if burning or pain is felt while it is being given. If the skin becomes red or swollen, call your healthcare provider. If a blister or scab develops, do not pop it or pick it. • This medicine will be given at a lower dose or not given while you are receiving radiation therapy. • Discuss with health care provider before taking any live vaccines. • Consult your healthcare provider before becoming pregnant, fathering a child, or breastfeeding. It may be important to use birth control while taking this medicine and for several months after treatment is completed. • In utero exposure may cause fetal harm.
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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