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Cyclophosphamide ( sy-cloe-FOSS-fuh-myde ) (Cytoxan®) What is this medication used for? It is used to destroy cancer cells by interfering with their growth cycle.
What does it look like? • Liquid • Tablet How is it given? • Into the vein (IV) or venous access device • By mouth What are the common side effects? • Nausea or vomiting • Loss of appetite • Hair loss (alopecia) • Low blood counts 1–2 weeks after treatment • Decrease in fertility What are the less common side effects? • Blood in the urine or bladder irritation • Metal taste in the mouth • Hormonal changes • Heart damage (with high doses) • Secondary cancer
Special instructions: • This medicine may cause bladder irritation. Liquids should be consumed before, during, and after the medicine is given; the patient should urinate frequently and check the amount and color of the urine. • If urination is painful or there is blood in the urine, call your healthcare provider. • A medicine called Mesna may be given to help prevent bladder irritation. • Chewing gum or sucking on hard candy while the medicine is given may decrease the metal taste. • Consult a healthcare provider before becoming pregnant, fathering a child, or breastfeeding. It may be important to use birth control while taking this medicine . • In utero exposure may cause fetal harm.
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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