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Activated Recombinant Factor VII ( ree-KOM-be-nant FAK-ter SEV-en ) (NovoSeven®) What is this medication used for?
Activated recombinant factor VII works by entering the bloodstream, targeting the site of injury, and helping in the formation of thrombin (a protein in the blood that causes the clotting of blood). It helps treat spontaneous bleeding episodes and helps prevent bleeding episodes after surgery in patients with hemophilia A or B when antibodies (inhibitors) to factor VII or factor IX are present and in patients with acquired hemophilia, Glanzmann thrombasthenia with refractoriness to platelet transfusions, or congenital factor VII deficiency.
What does it look like? • Liquid solution How is it given?
Special instructions: • Store vials under refrigeration. • Protect the medicine from light.
• Prior to reconstitution, bring the medicine to room temperature. Add diluent along the wall of the vial; do not inject directly onto the powder. Gently swirl until the powder is dissolved. • Administer over 2–5 minutes. • The reconstituted solution may be stored at room temperature or under refrigeration, but must be infused within 3 hours of reconstitution. • Do not store the reconstituted solution in syringes.
• Into the vein (IV) or venous access device What are the common side effects? • High blood pressure • Fever What are the less common side effects? • Headache
• Itching (pruritis) of skin • Reaction at injection site • Lower heart rate • Vomiting
What are the rare but serious side effects? • Blood clot in the leg or arm (deep vein thrombosis) • Blood clot in the lungs (pulmonary thrombosis) • Allergic reaction • Antibody (inhibitor) formation • Formation of blood clots in small vessels in organs (disseminated intravascular coagulopathy)
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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