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Sorafenib (soe-RAF-eh-nib) (Nexavar®) How does this medicine work? Used to treat certain types of cancer such as leukemias and thyroid cancer.
What does it look like? • Tablet How is it given? • By mouth (oral or po) What are the common side effects?
Special instructions: • Call a healthcare provider immediately if any of the following occur: severe abdominal pain associated with nausea and vomiting or chest pain, redness of the palms of hands or feet, tingling of the hands or feet, or flu like symptoms, such as fatigue, muscle aches, or low-grade fever. • Blood pressure may need to be monitored at home during treatment, especially in the first 6 weeks of treatment. • Avoid sun exposure, wear sunscreen and protective clothing • Tablets should be taken at least 1 hour before or 2 hours after eating. • Do not become pregnant, father a child, or breastfeed while taking this medication. It may be important to use birth control while taking this medicine.
• High blood pressure (hypertension) • Skin changes, including dryness • Delayed wound healing • Weight loss • Nausea • Hair loss (alopecia) • Changes to liver and pancreas function tests • Stomach (abdominal) pain • Muscle and joint pain (myalgia, arthralgia) • Feeling tired (fatigue, malaise)
• low platelet count (thrombocytopenia) • low white blood cell counts (neutropenia) What are the less common side effects? • Shortness of breath (dyspnea) • Rash, redness, swelling, pain, or peeling of palms of hands and soles of the feet • Damage to unborn child (birth defects) • Heart problems (rare but serious) • Difficulty breathing or swallowing • Bleeding from the gastrointestinal tract or the brain
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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