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Recombinant Factor IX ( ree-CUHM-bin-ant FAK-ter nyne ) (BeneFIX®, Ixinity®, Rixubis®) What is this medication used for? Recombinant factor IX incorporates the artificial factor VIII protein to temporarily replace factor IX deficiency. It is used to help prevent and control bleeding in patients with Hemophilia B.
What does it look like? • Liquid (created by mixing vial of powder and vial of liquid) How is it given?
Special instructions: • Before administering, the two vials must be mixed together using the manufacturer’s specific transfer device. • This medicine can be stored at room temperature for up to 6 months. Reconstituted solution should be stored at room temperature and used within 3 hours of preparation. • The first 10–20 administrations should be performed under medical supervision because there is a risk for severe allergic reaction. This risk is more common for patients with severe factor IX deficiency and certain genetic mutations. • Vial sizes vary. Administering more than the recommended dose is unlikely to cause problems. Infuse the entire contents of each vial. When in doubt, contact the prescribing provider before wasting the medicine. • Recombinant factor IX should be given before diagnostic procedures (e.g., computed tomography [CT] scan or magnetic resonance imaging [MRI]) when bleeding is suspected because bleeding will likely continue until the medicine is administered. Delays in treatment can result in life- or limb-threatening bleeding. • Contact your healthcare provider if bleeding continues despite treatment.
• Into the vein (IV) or venous access device What are the common side effects? • Headache • Discomfort at the IV site What are the less common side effects? • Allergic reaction (e.g., hives, itching, wheezing) • Nausea • Diarrhea • Fever • Development of an antibody (i.e., inhibitor)
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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