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Asparaginase ( as-PAH-rah-jin-ayse ) (Oncospar ®, Erwinia, PEG, L-Asparaginase, Elspar®, Rylaze ®,
Asparlas ®, cal-PEG®) What is this medication used for? It destroys cancer cells by interfering with their growth cycle.
What does it look like? • Liquid How is it given? • Into a muscle (IM)
Special instructions: • Some patients have severe allergic reactions (anaphylaxis), which include hives, chills, fever, low blood pressure, and shortness of breath. Vital signs will be monitored while the medicine is given and immediately after. If these symptoms occur at home, call your healthcare provider. If the symptoms are severe, call 911 (or your emergency number). • Medications to prevent an allergic reaction may be given prior to receiving asparaginase. • Signs of bleeding should be reported to your healthcare provider. • In utero exposure may cause fetal harm.
• Into the vein (IV) or venous access device What are the common side effects? • Loss of appetite • Redness, swelling, or soreness at the injection site if given IM • Nausea and vomiting • Allergic reaction (e.g., hives or difficulty breathing) What are the less common side effects? • Abnormal liver and pancreatic function tests • High blood sugar • Drowsiness or headache • Increased thirst or urination • High triglycerides or cholesterol • Severe allergic reaction • Alterations in the levels of blood clotting factors • Bleeding • Abdominal (belly) pain • Seizure • Fever
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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