2025 Medication Fact Sheets Full Document_100825

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Nystatin/Clotrimazole ( niss-TAH-tin/cloe-TRIM-ah-zole ) (Mycostatin®, Mycelex® Troche) What is this medication used for? It is an antifungal medicine used to prevent or treat fungal/yeast infections.

What does it look like? • Liquid • Tablet • Cream, ointment, or powder How is it given? • By mouth (oral or po; liquid is swished around before swallowing; tablet is dissolved in mouth) • Applied to skin (topical) What are the common side effects? • Nausea • Diarrhea • Itching or numbness in mouth What are the less common side effects? • Severe skin rash or reaction • Dark urine • Feeling tired (fatigue, malaise) • Stomach (abdominal) pain • Light-colored stools • Yellowing of the skin or eyes (jaundice)

Special instructions: • Shake the liquid well before each use. • Allow the liquid to coat the lining of the mouth by swishing it around before swallowing. • The tablet should be allowed to dissolve in the mouth. • Do not drink or eat anything for 5-10 minutes after taking the liquid or tablet. • Topical Nystatin should be applied only to the affected area as directed by the healthcare provider. It should not be applied to other areas of the body. Contact your healthcare provider if severe mouth sores develop or if there is difficulty swallowing. • Stop using topical Nystatin and call your doctor immediately for severe burning, itching, rash, pain, or other irritation occurs where the medicine is applied.

Notes from Your Healthcare Team

Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.

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