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Aprepitant/Fosaprepitant ( uh-PREP-i-tent/FOS-uh-PREP-i-tent ) (Emend®) What is this medication used for? Aprepitant (the oral form) and fosaprepitant (the IV form) help prevent immediate and delayed nausea and vomiting associated with chemotherapy. They work by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.
What does it look like? • Oral capsule • Pink oral suspension • Clear liquid (IV) How is it given? • By mouth
What are the rare side effects? • Rash and hives • Abnormal liver function tests Special instructions:
• Aprepitant may interact with many types of medications. Please check with your healthcare provider before your child takes this medication and report all medications you child is taking (including over the counter and herbal medicines) to your healthcare provider. • Call your healthcare provider immediately in the event of rash or hives. • This drug is used in combination with other antinausea medications such as ondansetron (Zofran®) and dexamethasone (Decadron®). • The dexamethasone (Decadron®) dosage should be reduced when used with aprepitant.
• Into the vein (IV) or venous access device What are the common side effects? • Fatigue • Low white blood cell count What are the less common side effects? • Pain at the injection site (IV form) • Muscle pain • Loss of appetite • Constipation or diarrhea • Hiccups • Somnolence (i.e., sleepiness and drowsiness) • Upset stomach and cramping • Dizziness and headache
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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