2025 Medication Fact Sheets Full Document_100825

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Liposomal Amphotericin B ( LYE-poe-SOE-mal AM-foe-TER-i-sin B ) (AmBisome®) What is this medication used for? Liposomal amphotericin B is used to treat fungal infections. It works by interfering with the cell membrane of the fungus.

What does it look like? • Liquid How is it given? • Into the vein (IV) or venous access device What are common side effects? • Diarrhea or constipation • Nausea or vomiting • Loss of appetite • Back pain • Stomach (abdominal) pain • Difficulty sleeping (insomnia) • Feeling tired or weak (fatigue, malaise) • Runny nose • Bad headaches • Chills • Sweating

What are less common side effects? • Allergic reaction, which might include rash or itching (pruritis) and red, swollen, blistered, or peeling skin, with or without fever • High or low blood pressure • Elevated heart rate • Dark urine • Upset stomach or stomach pain • Light-colored stools • Vomiting • Yellowing of the skin or eyes (jaundice) • Signs of infection such as fever, chills, sore throat, ear or sinus pain, or cough • Mood changes • Confusion • Muscle pain or weakness • Abnormal heartbeat that does not feel normal • Seizures • Black, tarry, or bloody stools • Dizziness

Notes from Your Healthcare Team

Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.

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