2025 Medication Fact Sheets Full Document_100825

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Leucovorin ( LOO-koe-VOR-in ) (Wellcovorin®) What is this medication used for? It is a vitamin that works to decrease the harm methotrexate can cause normal cells.

What does it look like? • Tablet • Liquid How is it given? • By mouth (oral or po)

Special instructions: • Each dose of this medicine must be taken at exactly the same time. Your healthcare provider will determine when to start and stop taking this medicine. • If vomiting occurs within 30 minutes of taking this medicine by mouth, call your healthcare provider. • If this medicine is not taken as directed, high doses of methotrexate can damage healthy cells in the body.

• Into the vein (IV) or venous access device What are the common side effects? • None What are the less common side effects? • Rash • Allergic reaction

• Seizures • Dizziness

Notes from Your Healthcare Team

Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.

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