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Hemlibra ( hem-libra ) (emicizumab-kxwh®) What is this medication used for?
Hemlibra is a bispecific antibody that is used to bind activated factor IX (factor 9) and factor X (factor 10) to help increase the potential for your blood to clot. It is used as routine prophylaxis to prevent or reduce the frequency of bleeding in patients with hemophilia A with or without factor VIII (factor 8) inhibitors.
What does it look like? • Liquid How is it given?
Special instructions: • A loading dose of this medication must be given weekly for the first 4 weeks of administration. It will be then followed by a maintenance dose. Maintenance dosing is based on provider preference and with consideration of a regimen that will increase patient adherence. • If a dose of Hemlibra is missed, administer it as soon as possible and then resume usual dosing schedule. Do not take two doses on the same day to make up for a missed dose. • This medication might interfere with other laboratory tests which evaluate blood clotting. You should let your health care provider know that you are on Hemlibra before having lab testing performed. .
• Into the skin (subcutaneously or subq) What are the common side effects? • Injection site reactions (redness, swelling, itching, or pain around the site of injection) • Headache • Joint pain or aching What are the less common side effects? • Thrombotic microangiopathy (TMA) - a condition involving blot clots and injury to the small vessels that may cause harm to your kidneys, brain or other organs. • Blood clots – which may form in blood vessels in your arm, leg, lung, or head. Symptoms of blood clots or TMA include: • Confusion • Stomach, chest, or back pain • Weakness • Nausea or vomiting • Swelling, pain, or redness in arm or leg • Decreased urination • Eye pain, trouble seeing, or vision changes • Headache • Fast heart rate • Shortness of breath or coughing up blood • Breakthrough bleeding events – though rare, this could indicate a loss in efficacy of Hemlibra
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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