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Glucarpidase ( gloo-KAR-pid-ase ) (Voraxaze®) What is this medication used for?
Glucarpidase is used to treat dangerously high levels of methotrexate in the blood and severe kidney damage during high-dose methotrexate infusions. It breaks methotrexate into two inactive metabolites and provides a pathway of elimination that does not further damage the kidneys.
• Severe allergic reactions (anaphylaxis) • Severe dizziness or passing out (loss of consciousness) • Flushing, feeling hot • Numbness or tingling in the hands or feet (peripheral neuropathy) Special instructions: • Blood tests will be done to check kidney function and methotrexate levels.
What does it look like? • Liquid How is it given?
• Into the vein (IV) or venous access device What are the common side effects? • Headache • Nausea • Vomiting What are the less common side effects?
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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