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Amifostine ( am-ih-FOS-teen ) (Ethyol®) What is this medication used for? Amifostine helps protect the kidneys, bladder, bone marrow, and saliva from the effects of chemotherapy and radiation therapy.
What does it look like? • Liquid How is it given?
Special instructions: • Electrolyte levels will need to be monitored closely while this medicine is taken. • Blood pressure medicines should not be given for 24 hours before taking amifostine. • Blood pressure will be monitored every 3–5 minutes during amifostine infusion. • Extra IV fluid is given before an amifostine infusion to decrease the risk of low blood pressure. • Anti-nausea medications are given prior to an amifostine infusion to prevent nausea and vomiting. • It is necessary to lie flat during the infusion and for up to 30 minutes afterward. • Doses of this medicine are given immediately before radiation or chemotherapy. • Calcium supplements will be given as needed to correct low calcium levels. • In utero exposure may cause fetal harm.
• Into the vein (IV) or venous access device What are the common side effects? • Low blood pressure • Severe nausea and vomiting • Flushing • Rash What are the less common side effects? • Dizziness • Sleepiness • Sneezing • Low levels of calcium in the blood
• Rash, chills, and hiccups • Severe allergic reaction
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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