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Fluorouracil (flore-oh-YUR-uh-sil ) (5-FU, Efudex®) What is this medication used for? Fluorouracil destroys cancer cells by interfering with their growth cycle.
What does it look like? • Liquid How is it given? • Into the vein (IV) What are the common side effects? • Loss of appetite (anorexia) • Nausea and vomiting • Diarrhea • Mouth sores (mucositis) • Low blood cell counts 10–14 days after treatment
What are the less common side effects? • Skin rash or darkening of the skin, especially on the face and hands • Hair loss (alopecia) • Skin sensitivity to sunlight • Watery eyes and eye sensitivity to light • Tingling in hands and feet (peripheral neuropathy) Special instructions: • While taking this medicine, use sunscreen and wear protective clothing and sunglasses when outdoors. • Consult your healthcare provider before becoming pregnant, fathering a child, or breastfeeding. It may be important to use birth control while taking this medicine and for several months after treatment is completed. • In utero exposure may cause fetal harm.
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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