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Fludarabine ( floo-DAYR-uh-been ) (Fludarabine phosphate, F-ara-AMP, Fludara®) What is this medication used for? Fludarabine is used to treat leukemias. It also is part of a conditioning regimen prior to stem cell transplantation. It works by stopping cancer cells from making and repairing DNA so that they cannot grow and multiply.
What does it look like? • Liquid • Tablet How is it given? • Into the vein (IV) or venous access device • By mouth (oral or po) What are the common side effects? • Mild nausea, vomiting, and diarrhea • Mouth sores • Feeling tired (fatigue, malaise) • Loss of appetite • Headache • Low blood counts 2–4 weeks after treatment
What are the less common side effects? • Abnormal liver function tests • Muscle aches • Puffiness • Numbness or tingling in the arms, feet, and hands (peripheral neuropathy) • Lung damage • Chills • Changes in vision, seizure, or other central nervous system changes Special instructions: • Notify your healthcare provider if you have fever, sore throat, bleeding, or difficulty breathing. • Fludarabine tablets must not be crushed or altered. • Notify your healthcare provider immediately if vision changes, agitation, confusion, or seizure occur. • In utero exposure may cause fetal harm.
• Fever • Rash
Notes from Your Healthcare Team
Not all of the possible side effects of this medicine and precautions related to taking it are covered in this information sheet. For a complete list of side effects and precautions, ask your healthcare professional (doctor, nurse, pharmacist) for a manufacturer’s package insert or another reference.
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